Demographic variations in maxillary pathologic lesions - an institutional study
Journal of Contemporary Issues in Business and Government,
2020, Volume 26, Issue 2, Pages 260-269
10.47750/cibg.2020.26.02.033
Abstract
A variety of benign and malignant lesions involve the maxilla and maxillary sinus. The presenting features, symptomatology and advanced diagnostic imaging techniques help in achieving a differential diagnosis however histopathological examination remains the mainstay of definitive diagnosis. This study aims to identify the frequency of isolated maxillary pathologic lesions (benign and malignant) and its gender and age distribution. After clearance from the institutional ethical committee, a retrospective study was performed for a period of ten months from June 2019 to March 2020 in our institution. 90 cases of pathology were reviewed out of which 29 were included in the study based on the inclusion criteria. 68.97% males and 31.03% females reported with pathologic lesions of the maxilla alone in our center. Malignant maxillary lesions show the highest frequency of occurrence in 17.24% in the 41-60 age group (p value-0.233). Treatment modalities used for various lesions diagnosed in the maxilla showed the highest degree of association with surgical excision being the most commonly performed for malignant lesions and enucleation for cysts and benign tumors (p value- 0.000). Maxillary benign pathological lesions have a tendency to mimic malignant lesions. Hence it is important to document and identify lesions most commonly encountered in a particular population to provide for adequate and appropriate treatment care needs.
Main Subjects:
- Abhinav, R. P. et al. (2019) ‘The Patterns and Etiology of Maxillofacial Trauma in South India’, Annals of maxillofacial surgery, 9(1), pp. 114–117.
- Abraham, S. et al. (2005) ‘Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9)’, Journal of periodontology, 76(4), pp. 497–502.
- Adisa, A. O. et al. (2016) ‘A retrospective review of 61 cases of adenomatoid odontogenic tumour seen in five tertiary health facilities in Nigeria’, The Pan African medical journal, 24, p. 102.
- Almeida Júnior, V. R. de et al. (2020) ‘Simultaneous presentation of juvenile ossifying fibroma in the maxilla and mandible: a case report’, International journal of surgery case reports, 71, pp. 285–289.
- Alramadhan, S. A. et al. (2020) ‘Retrospective Study of Buccal Mucosal Salivary Neoplasms’, Head and neck pathology. doi: 10.1007/s12105-020-01190-8.
- Antunes, L. de O. et al. (2018) ‘Osteomyelitis of the maxilla caused by sp’, Radiologia brasileira, 51(5), pp. 340–341.
- Arani, R., Shareef, S. N. H. A. and Khanam, H. M. K. (2019) ‘Mucormycotic Osteomyelitis Involving the Maxilla: A Rare Case Report and Review of the Literature’, Case reports in infectious diseases, 2019, p. 8459296.
- Arja, C. et al. (2013) ‘Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease’, Respirology , 18(7), pp. 1069–1075.
- de Arruda, J. A. A. et al. (2018) ‘Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review’, Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 47(8), pp. 721–730.
- Banasser, A. M. et al. (2020) ‘Odontogenic Myxoma: A 23-Year Retrospective Series of 38 Cases’, Head and neck pathology. doi: 10.1007/s12105-020-01191-7.
- Carton, J. (2017) ‘Head and neck pathology’, Oxford Medicine Online. doi: 10.1093/med/9780198759584.003.0006.
- Chee, C. A. K. M. et al. (2014) ‘Surgical ciliated cyst of the maxilla following maxillary osteotomy: a case report’, Oral Surgery, pp. 39–41. doi: 10.1111/ors.12041.
- Christabel, A. et al. (2016) ‘Comparison of pterygomaxillary dysjunction with tuberosity separation in isolated Le Fort I osteotomies: a prospective, multi-centre, triple-blind, randomized controlled trial’, International journal of oral and maxillofacial surgery, 45(2), pp. 180–185.
- Christensen, R. W. (1956) ‘Complex composite odontoma involving the maxilla and maxillary sinus’, Oral Surgery, Oral Medicine, Oral Pathology, pp. 1156–1164. doi: 10.1016/0030-4220(56)90185-2.
- Cunningham, D. J. (1818) Cunningham’s textbook of anatomy.
- Dalgorf, D. and Higgins, K. (2008) ‘Reconstruction of the midface and maxilla’, Current opinion in otolaryngology & head and neck surgery, 16(4), pp. 303–311.
- Devaki, T., Sathivel, A. and BalajiRaghavendran, H. R. (2009) ‘Stabilization of mitochondrial and microsomal function by polysaccharide of Ulva lactuca on D-Galactosamine induced hepatitis in rats’, Chemico-biological interactions, 177(2), pp. 83–88.
- Dhupar, V., Akkara, F. and Khandelwal, P. (2016) ‘An unusually large aggressive adenomatoid odontogenic tumor of maxilla involving the third molar: A clinical case report’, European journal of dentistry, 10(2), pp. 277–280.
- Dong, D. et al. (2020) ‘Fibro-osseous Lesions of Paranasal Sinus and Craniofacial Region: A Retrospective Study of 282 Cases’, The Laryngoscope. doi: 10.1002/lary.28529.
- Ezhilarasan, D. (2018) ‘Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective’, Arab journal of gastroenterology: the official publication of the Pan-Arab Association of Gastroenterology, 19(2), pp. 56–64.
- Ezhilarasan, D., Sokal, E. and Najimi, M. (2018) ‘Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets’, Hepatobiliary & pancreatic diseases international: HBPD INT, 17(3), pp. 192–197.
- Farias, J. G. et al. (2019) ‘Epidemiological study of intraosseous lesions of the stomatognathic or maxillomandibular complex diagnosed by a Reference Centre in Brazil from 2006-2017’, The British journal of oral & maxillofacial surgery, 57(7), pp. 632–637.
- Fehrenbach, M. J. and Herring, S. W. (2013) Illustrated Anatomy of the Head and Neck - E-Book. Elsevier Health Sciences.
- George, S. et al. (2017) ‘Giant Peripheral Ossifying Fibroma of Maxilla’, Indian Journal of Dental Education, pp. 74–77. doi: 10.21088/ijde.0974.6099.10217.15.
- Ghazawi, F. M. et al. (2020) ‘Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada’, Journal of cutaneous medicine and surgery, p. 1203475420915448.
- Goto, M. et al. (2020) ‘A rare case of odontogenic keratocyst extending into the sphenoid bone from the maxilla’, International journal of surgery case reports, 71, pp. 132–138.
- Himalstein, M. R. (1967) ‘OSTEOMYELITIS OF THE MAXILLA DUE TO AN ANAEROBIC ORGANISM’, The Laryngoscope, pp. 559–561. doi: 10.1288/00005537-196704000-00011.
- Jain, S. V. et al. (2019) ‘Evaluation of Three-Dimensional Changes in Pharyngeal Airway Following Isolated Lefort One Osteotomy for the Correction of Vertical Maxillary Excess: A Prospective Study’, Journal of Maxillofacial and Oral Surgery, pp. 139–146. doi: 10.1007/s12663-018-1113-4.
- Jesudasan, J. S., Wahab, P. U. A. and Sekhar, M. R. M. (2015) ‘Effectiveness of 0.2% chlorhexidine gel and a eugenol-based paste on postoperative alveolar osteitis in patients having third molars extracted: a randomised controlled clinical trial’, The British journal of oral & maxillofacial surgery, 53(9), pp. 826–830.
- J, P. C. et al. (2018) ‘Prevalence and measurement of anterior loop of the mandibular canal using CBCT: A cross sectional study’, Clinical implant dentistry and related research, 20(4), pp. 531–534.
- Kalra, A. et al. (2018) ‘A Bag of Marbles: A Fascinating Compound Odontoma of the Maxilla’, Pediatric dentistry, 40(2), pp. 140–142.
- Kammer, P. V., Mello, F. W. and Rivero, E. R. C. (2020) ‘Comparative analysis between developmental and inflammatory odontogenic cysts: retrospective study and literature review’, Oral and maxillofacial surgery, 24(1), pp. 73–84.
- Karakida, K. et al. (2010) ‘Multiple giant cell tumors in maxilla and skull complicating Paget’s disease of bone’, The Tokai journal of experimental and clinical medicine, 35(3), pp. 112–117.
- Katiyar, A. et al. (2019) ‘Trauma to Tumor: A Hunt of Adenomatoid Odontogenic Tumor-A Rare Case Report’, International journal of clinical pediatric dentistry, 12(4), pp. 366–369.
- Kilinc, A. et al. (2017) ‘Benign tumors and tumor-like lesions of the oral cavity and jaws: An analysis of 709 cases’, Nigerian journal of clinical practice, 20(11), pp. 1448–1454.
- Kochanowski, N. E. et al. (2018) ‘Radiographic Diagnosis of Fibrous Dysplasia in Maxilla’, Cureus. doi: 10.7759/cureus.3127.
- Kolur, T., Nair, S. C. and Kumar, B. (2015) ‘Osteonecrosis of maxilla secondary to bisphosphonate therapy: a case report’, Journal of maxillofacial and oral surgery, 14(Suppl 1), pp. 52–56.
- Krishnaswamy, H. et al. (2020) ‘Investigation of air conditioning temperature variation by modifying the structure of passenger car using computational fluid dynamics’, Thermal Science, 24(1 Part B), pp. 495–498.
- Kühnel, T. S. and Reichert, T. E. (2015) ‘Trauma of the midface’, GMS current topics in otorhinolaryngology, head and neck surgery, 14, p. Doc06.
- Kumar, S. (2017a) ‘KNOWLEDGE, ATTITUDE AND AWARENESS OF DENTAL UNDERGRADUATE STUDENTS REGARDING HIV/AIDS PATIENTS’, Asian Journal of Pharmaceutical and Clinical Research, 10(5), p. 175.
- Kumar, S. (2017b) ‘RELATIONSHIP BETWEEN DENTAL ANXIETY AND PAIN EXPERIENCE DURING DENTAL EXTRACTIONS’, Asian Journal of Pharmaceutical and Clinical Research, p. 458. doi: 10.22159/ajpcr.2017.v10i3.16518.
- Kumar, S. (2017c) ‘THE EMERGING ROLE OF BOTULINUM TOXIN IN THE TREATMENT OF OROFACIAL DISORDERS: LITERATURE UPDATE’, Asian Journal of Pharmaceutical and Clinical Research, p. 21. doi: 10.22159/ajpcr.2017.v10i9.16914.
- Kumar, S. and Rahman, R. (2017) ‘KNOWLEDGE, AWARENESS, AND PRACTICES REGARDING BIOMEDICAL WASTE MANAGEMENT AMONG UNDERGRADUATE DENTAL STUDENTS’, Asian Journal of Pharmaceutical and Clinical Research, 10(8), p. 341.
- Kumar, S. and Sneha, S. (2016) ‘KNOWLEDGE AND AWARENESS REGARDING ANTIBIOTIC PROPHYLAXIS FOR INFECTIVE ENDOCARDITIS AMONG UNDERGRADUATE DENTAL STUDENTS’, Asian Journal of Pharmaceutical and Clinical Research, p. 154. doi: 10.22159/ajpcr.2016.v9s2.13405.
- Larrabee, W. F., Makielski, K. H. and Henderson, J. L. (2004) Surgical Anatomy of the Face. Lippincott Williams & Wilkins.
- Lee, H. M. et al. (2016) ‘Compound Type Odontoma at Maxilla’, Archives of Craniofacial Surgery, p. 96. doi: 10.7181/acfs.2016.17.2.96.
- Leung, Y. Y., Wong, W. Y. and Cheung, L. K. (2012) ‘Surgical ciliated cysts may mimic radicular cysts or residual cysts of maxilla: report of 3 cases’, Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 70(4), pp. e264–9.
- Lev, D. and Artzi, Z. (2020) ‘The Anatomy of the Maxilla and the Mandible’, Bone Augmentation by Anatomical Region, pp. 1–16. doi: 10.1002/9781119427926.ch1.
- Li, S. H. et al. (2020) ‘Endoscope-assisted Surgery in the Treatment of Dentigerous Cyst Involving the Maxillary Sinus - Report of Two Cases’, The Chinese journal of dental research: the official journal of the Scientific Section of the Chinese Stomatological Association , 23(1), pp. 71–76.
- Luo, H.-Y. and Li, T.-J. (2009) ‘Odontogenic tumors: a study of 1309 cases in a Chinese population’, Oral oncology, 45(8), pp. 706–711.
- MacDonald, D., Martin, M. and Nguyen, C. (2020) ‘Malignant lesions in the anterior maxilla’, Clinical radiology, 75(7), pp. 497–506.
- Macedo, D. de V. et al. (2020) ‘Ossifying fibroma in the maxilla and orbital floor: report of an uncommon case’, Journal of the Korean Association of Oral and Maxillofacial Surgeons, 46(3), pp. 204–207.
- Malli Sureshbabu, N. et al. (2019) ‘Concentrated Growth Factors as an Ingenious Biomaterial in Regeneration of Bony Defects after Periapical Surgery: A Report of Two Cases’, Case reports in dentistry, 2019, p. 7046203.
- Manivannan, I. et al. (2017) ‘Tribological and surface behavior of silicon carbide reinforced aluminum matrix nanocomposite’, Surfaces and Interfaces, 8, pp. 127–136.
- Marimuthu, M. et al. (2018) ‘Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma’, Indian journal of dental research: official publication of Indian Society for Dental Research, 29(3), pp. 291–297.
- Maruyama, N. et al. (2020) ‘Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma’, Diagnostics (Basel, Switzerland), 10(4). doi: 10.3390/diagnostics10040218.
- Meethal, A. C. (2016) ‘Actinomycotic Osteomyelitis of the Maxilla – A Delusive Presentation’, JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi: 10.7860/jcdr/2016/19171.8086.
- Mehta, M. et al. (2019) ‘Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases’, Chemico-biological interactions, 308, pp. 206–215.
- Mohanty, R. et al. (2019) ‘A rare nonsyndromic case of adenomatoid odontogenic tumor associated with multiple impacted supernumerary teeth’, National journal of maxillofacial surgery, 10(1), pp. 114–117.
- ‘Monostotic Type of Fibrous Dysplasia of Maxilla’ (2016) Indian Journal of Dental Advancements. doi: 10.5866/2016.8.10263.
- Mooney, W. W. W. et al. (2003) ‘Recurrent giant cell tumour of the maxilla associated with both Paget’s disease and primary hyperparathyroidism’, ANZ journal of surgery, 73(10), pp. 863–864.
- Morris, A. L. and Tadi, P. (2020) ‘Anatomy, Head and Neck, Teeth’, in StatPearls. Treasure Island (FL): StatPearls Publishing.
- Murphy, C. et al. (2014) ‘Management of Large Erupting Complex Odontoma in Maxilla’, Case Reports in Pediatrics, pp. 1–3. doi: 10.1155/2014/963962.
- Muthu, K. (2017) ‘Ossifying Fibroma of Maxilla’, Austin Journal of Dentistry. doi: 10.26420/austinjdent.2017.1088.
- Neelakantan, P. et al. (2010) ‘Root and Canal Morphology of Mandibular Second Molars in an Indian Population’, Journal of endodontics, 36(8), pp. 1319–1322.
- Neelakantan, P. et al. (2015) ‘Photoactivation of curcumin and sodium hypochlorite to enhance antibiofilm efficacy in root canal dentin’, Photodiagnosis and photodynamic therapy, 12(1), pp. 108–114.
- Nogueira, A. S. et al. (2014) ‘Simultaneous occurrence of dentigerous cyst and residual cyst in the maxilla’, Brazilian journal of otorhinolaryngology, 80(1), pp. 88–89.
- de Oliveira, M. A. et al. (2019) ‘The Importance of Histopathological Examination to the Final Diagnosis of Peripheral Odontogenic Tumors: A Case Report of a Peripheral Odontoma’, Case reports in dentistry, 2019, p. 9712816.
- Packiri, S., Gurunathan, D. and Selvarasu, K. (2017) ‘Management of Paediatric Oral Ranula: A Systematic Review’, Journal of clinical and diagnostic research: JCDR, 11(9), pp. ZE06–ZE09.
- Patil, S. B. et al. (2017) ‘Comparison of Extended Nasolabial Flap Versus Buccal Fat Pad Graft in the Surgical Management of Oral Submucous Fibrosis: A Prospective Pilot Study’, Journal of maxillofacial and oral surgery, 16(3), pp. 312–321.
- Pattnaik, B. et al. (2017) ‘Osteomyelitis of maxilla: A rarity’, Annals of International medical and Dental Research. doi: 10.21276/aimdr.2017.3.3.de2.
- Patturaja, K. and Pradeep, D. (2016) ‘Awareness of Basic Dental Procedure among General Population’, Research Journal of Pharmacy and Technology, p. 1349. doi: 10.5958/0974-360x.2016.00258.4.
- Rajendran, A. and Sivapathasundharam, B. (2014) Shafer’s Textbook of Oral Pathology. Elsevier Health Sciences.
- Ramamoorthi, S., Nivedhitha, M. S. and Divyanand, M. J. (2015) ‘Comparative evaluation of postoperative pain after using endodontic needle and EndoActivator during root canal irrigation: A randomised controlled trial’, Australian endodontic journal: the journal of the Australian Society of Endodontology Inc, 41(2), pp. 78–87.
- Ramshankar, V. et al. (2014) ‘Risk stratification of early stage oral tongue cancers based on HPV status and p16 immunoexpression’, Asian Pacific journal of cancer prevention: APJCP, 15(19), pp. 8351–8359.
- Rao, T. D. and Santhosh Kumar, M. P. (2018) ‘Analgesic Efficacy of Paracetamol Vs Ketorolac after Dental Extractions’, Research Journal of Pharmacy and Technology, p. 3375. doi: 10.5958/0974-360x.2018.00621.2.
- Ravindiran, M. and Praveenkumar, C. (2018) ‘Status review and the future prospects of CZTS based solar cell – A novel approach on the device structure and material modeling for CZTS based photovoltaic device’, Renewable and Sustainable Energy Reviews, 94, pp. 317–329.
- Regezi, J. A., Sciubba, J. and Jordan, R. C. K. (2012) Oral Pathology - E-Book: Clinical Pathologic Correlations. Elsevier Health Sciences.
- Sadaksharam, J. and Murugesan, M. (2019) ‘Osteomyelitis of Maxilla: A Rare Finding from a Radiologist Point of View’, Contemporary clinical dentistry, 10(2), pp. 394–396.
- Samuel, S. R., Acharya, S. and Rao, J. C. (2020) ‘School Interventions-based Prevention of Early-Childhood Caries among 3-5-year-old children from very low socioeconomic status: Two-year randomized trial’, Journal of public health dentistry, 80(1), pp. 51–60.
- Sathish, T. and Karthick, S. (2020) ‘Wear behaviour analysis on aluminium alloy 7050 with reinforced SiC through taguchi approach’, Journal of Materials Research and Technology, 9(3), pp. 3481–3487.
- Seehra, J., Sloan, P. and Oliver, R. J. (2009) ‘Paget’s disease of bone and osteonecrosis’, Dental update, 36(3), pp. 166–8, 171–2.
- Seo, Y.-K. et al. (2019) ‘Diagnostic considerations in central odontogenic fibroma of the maxilla: 2 case reports’, Imaging science in dentistry, 49(3), pp. 229–234.
- Serindere, G. et al. (2019) ‘Comparison of Head and Neck Cancer Distribution in Turkish and Syrian Populations’, Iranian journal of public health, 48(10), pp. 1810–1816.
- Shanmugam, V. U. et al. (2018) ‘Fibrous Dysplasia of Maxilla - Surgical Sculpting for Aesthetics’, Journal of Medical Science And clinical Research. doi: 10.18535/jmscr/v6i8.111.
- Shimmura, H. et al. (2020) ‘Metastasis of Papillary Thyroid Carcinoma to the Maxillary Sinus: Case Report and Review of the Literature’, Case reports in otolaryngology, 2020, p. 4056901.
- Silva, L. P. et al. (2018) ‘A retrospective multicentre study of cystic lesions and odontogenic tumours in older people’, Gerodontology, 35(4), pp. 325–332.
- Sriram, G. and Shetty, R. P. (2008) ‘Odontogenic tumors: a study of 250 cases in an Indian teaching hospital’, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, pp. e14–e21. doi: 10.1016/j.tripleo.2008.02.021.
- Su, C.-W. et al. (2019) ‘Spontaneous osteosarcoma transformation of fibrous dysplasia in maxilla’, Journal of dental sciences, 14(2), pp. 219–222.
- Sumathi, C. et al. (2014) ‘Production of prodigiosin using tannery fleshing and evaluating its pharmacological effects’, TheScientificWorldJournal, 2014, p. 290327.
- Surapaneni, K. M. and Jainu, M. (2014) ‘Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis’, Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 65(1), pp. 67–74.
- Surapaneni, K. M., Priya, V. V. and Mallika, J. (2014) ‘Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH)’, European review for medical and pharmacological sciences, 18(18), pp. 2736–2741.
- Sweta, V. R., Abhinav, R. P. and Ramesh, A. (2019) ‘Role of Virtual Reality in Pain Perception of Patients Following the Administration of Local Anesthesia’, Annals of maxillofacial surgery, 9(1), pp. 110–113.
- Tamiolakis, P. et al. (2019) ‘Demographic and Clinical Characteristics of 5294 Jaw Cysts: A Retrospective Study of 38 Years’, Head and neck pathology, 13(4), pp. 587–596.
- Thakur, G. et al. (2011) ‘Juvenile ossifying fibroma of the maxilla’, Case Reports, pp. bcr0220113896–bcr0220113896. doi: 10.1136/bcr.02.2011.3896.
- Thompson, L. D. R. and Bishop, J. A. (2017) Head and Neck Pathology E-Book: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Health Sciences.
- Wanjari, P. V., Wanjari, S. and Bhowate, R. (2011) ‘Erupting complex odontoma of maxilla: A case report’, Journal of Pierre Fauchard Academy (India Section), pp. 65–68. doi: 10.1016/s0970-2199(11)50004-9.
- Ward, P. H., Alley, C. and Owen, R. (1969) ‘MONOSTOTIC FIBROUS DYSPLASIA OF THE MAXILLA’, The Laryngoscope, pp. 1295–1306. doi: 10.1288/00005537-196907000-00007.
- Xia, R.-H. et al. (2020) ‘Ameloblastoma with mucous cells: A clinicopathological, BRAF mutation, and MAML2 rearrangement study’, Oral diseases, 26(4), pp. 805–814.
- Zhuoying, C. and Fengguo, Y. (2019) ‘Huge erupted complex odontoma in maxilla’, Oral and Maxillofacial Surgery Cases, p. 100096. doi: 10.1016/j.omsc.2019.100096.
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