Human Genetic Variations Associated with Periodontitis- A Mini Review
Journal of Contemporary Issues in Business and Government,
2021, Volume 27, Issue 2, Pages 580-586
AbstractPeriodontitis (PD) is a complex, multifactorial disease which involves participation of microbial and host factors. Microbes activate inflammatory response in the host which stimulates the periodontal cells to secrete metalloproteinases and other proteolytic enzymes eventually resulting in the tissue destruction and bone resorption. Numerous experimental reports have gathered information related to the potential biomarkers involved in PD. Genetic component of the host as well as the microorganism has been shown to play a pivotal role in the pathogenesis of the disease. Human genetic variation is considered to be a susceptibility factor in relation to PD. These variations could make an individual resistant or susceptible to infections caused by the microorganisms. Also, other factors such as food habits, lifestyle, smoking, alcoholism and poor oral hygiene practice can aggravate the disease. The magnitude of the disease PD that a patient develops is due to factors related to the individual’s response to the bacterial colonization. Several inflammatory markers and the genes encoded by them are discussed in the present review. Thus the review provides a general overview of the genes and their proteins in association with different forms of PD.
- Bashir, M.M., Hussain, M., Ahmad, D., Tipu, H.N. 2018. Leukocyte Adhesion Deficiency Type 1 with Low Expression of CD 11b. 28(6):S87-S88. doi:10.29271/jcpsp.2018.06.S87
- Chai, L., Song, Y.Q., Zee, K.Y., Leung, W.K. 2010 SNPs of Fc-gamma receptor genes and chronic periodontitis. J Dent Res. 89(7):705-710. doi:10.1177/0022034510365444.
- Feng, X., Liu, J. 2020 Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis. Gene. 729:144227. doi:10.1016/j.gene.2019.144227
- Fraser, D.A., Loos, B.G., Boman, U., et al. 2003 Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis. Acta Odontol Scand. 61(5):297-302. doi:10.1080/00016350310006168
- Girija, A.S.S., Shoba, G. & Priyadharsini, J.V. (2020). Accessing the T-Cell and B-Cell Immuno-Dominant Peptides from A.baumannii Biofilm Associated Protein (bap) as Vaccine Candidates: A Computational Approach. [Epub Ahead of print]. doi: 10.1007/s10989-020-10064-0
- Hewitt, C., McCormick, D., Linden, G., et al. 2004 The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat. 23(3):222-228. doi:10.1002/humu.10314.
- Jin, S.H., Guan, X.Y., Liang, W.H., et al. 2016. TLR4 polymorphism and periodontitis susceptibility:A meta-analysis. Medicine (Baltimore). 95(36):e4845.
- Silva, N., Abusleme, L., Bravo, D., et al. 2015. Host response mechanisms in periodontal diseases. J Appl Oral Sci. 23(3):329-355. doi:10.1590/1678-775720140259.
- Sohaib Shahzan, M., Smiline Girija A.S.,Vijayashree Priyadharsini, J. 2019 A computational study targeting the mutated L321F of ERG11 gene in C . albicans,associated with fluconazole resistance with bio active compounds from Acacianilotica. J Mycol Med .2019;29(4):303-309.doi:10.1016/J.my ced.2019.100899.
- Thumbigere Math, V., Rebouças, P., Giovani, P.A., et al. 2018 Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response. JDR Clin Trans Res. 3(1):35-46. doi:10.1177/2380084417724117
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